NEW DISCOVERY TO REDUCE CHOLESTEROL

Cardiovascular diseases are the number one cause of death globally. And one of the major culprits involved — in arteriosclerosis, for example — is cholesterol. There is therefore a considerable need for an effective method of treatment against increased cholesterol. Now, Danish researchers have made a discovery that may change how it is treated.
The researchers have identified a new so-called receptor system, located in all the cells in the body. The receptor, which is called sortilin, has a decisive influence on the protein PCSK9, which is of great importance for the body’s ability to deal with the harmful LDL cholesterol.
New strategy for cholesterol treatment
Ten years ago it was discovered that the level of LDL cholesterol fell if you inhibited PCSK9. PCSK9-inhibiting drugs have since become the new hope within cholesterol treatment and the first products will probably be approved this year. The discovery is one of the biggest biomedical success stories in recent times, as it is normally takes 20 years before basic research can be converted into a product. The high pace and great focus on the effect has, however, meant that only a few people have conducted research into how the body itself regulates PCSK9.
Possible alternative to statins
The positive effect of inhibiting sortilin has been demonstrated in mice and studies in humans suggest that the same correlation is present here. The next step is now larger studies on humans. The hope is that the discovery can be used to develop medicine that can act as an alternative to statins, which are the most widely used cholesterol-reducing medication. Particularly because not everyone can either tolerate or benefit from statins.