Brand & Generic Names

Marinol

Basic Information

• Habit forming? Yes
• Prescription needed? Yes
• Available as generic? No
• Drug class: Antiemetic

Uses

• Prevents nausea and vomiting that may accompany taking anticancer medication (cancer chemotherapy). Should not be used unless other antinausea medicines fail.
• Appetite stimulant.

Dosage & Usage Information

How to take:
Capsule--Swallow with liquid.

When to take:
Under supervision, a total of no more than 4 to 6 doses per day, every 2 to 4 hours after cancer chemotherapy for prescribed number of days.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Affects nausea and vomiting center in brain to make it less irritable following cancer chemotherapy. Exact mechanism is unknown.

Time lapse before drug works:
2 to 4 hours.

Don't take with:
Non-prescription drugs without consulting doctor.
Drugs in interaction section without consulting doctor.

Overdose

SYMPTOMS:
Pounding, rapid heart rate; high or low blood pressure; confusion; hallucinations; drastic mood changes; nervousness or anxiety.

WHAT TO DO:

Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects

Life-threatening:

In case of overdose, see Overdose section.

Common:

• Rapid, pounding heartbeat.
• Dizziness, irritability, drowsiness, euphoria, decreased coordination.
• Red eyes, dry mouth.

Infrequent:

• Depression, anxiety, nervousness, headache, hallucinations, dramatic mood changes.
• Blurred or changed vision.

Rare:

• Rapid heartbeat, fainting, frequent or difficult urination, convulsions, shortness of breath.
• Paranoia, nausea, loss of appetite, dizziness when standing after sitting or lying down, diarrhea.

Warnings & Precautions

Don't take if:

• Your nausea and vomiting is caused by anything other than cancer chemotherapy.
• You are sensitive or allergic to any form of marijuana or sesame oil.
• Your cycle of chemotherapy is longer than 7 consecutive days. Harmful side effects may occur.

Before you start, consult your doctor:

• If you have heart disease or high blood pressure.
• If you are an alcoholic or drug addict.
• If you are pregnant or intend to become pregnant.
• If you are nursing an infant.
• If you have schizophrenia or a manic-depressive disorder.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Studies inconclusive on harm to unborn child. Decide with you doctor whether drug benefits justify risk to unborn child.

Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor about maintaining milk supply.

Infants & children:
Not recommended.

Prolonged use:

• Avoid. Habit forming.
• Talk to your doctor about the need for follow-up medical examinations or laboratory studies to check heart function.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs.

Discontinuing:
Withdrawal effects such as irritability, insomnia, restlessness, sweating, diarrhea, hiccups, loss of appetite and hot flashes may follow abrupt withdrawal within 12 hours. Should they occur, these symptoms will probably subside within 96 hours.

Others:
Store in refrigerator.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Anesthetics*	Oversedation.
Anticonvulsants*	Oversedation.
Antidepressants,	Oversedation.
Antihistamines*	Oversedation.
Barbiturates*	Oversedation.
Clozapine	Toxic effect on the central nervous
	system.
Ethinamate	Dangerous increased effects of
	ethinamate. Avoid combining.
Fluoxetine	Increased depressant effects of
	both drugs.
Guanfacine	May increase depressant effects of
	either drug.
Leucovorin	High alcohol content of leucovorin
	may cause adverse effects.
Methyprylon	Increased sedative effect, perhaps
	to dangerous level. Avoid.
Molindone	Increased effects of both drugs.
	Avoid.
Muscle relaxants*	Oversedation.
Nabilone	Greater depression of central
	nervous system.
Narcotics*	Oversedation.
Sedatives*	Oversedation.
Sertraline	Increased depressive effects
	of both drugs.
Tranquilizers*	Oversedation.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Oversedation.
Beverages:	No problems expected.
Cocaine:	No problems expected.
Foods:	No problems expected.
Marijuana:	Oversedation.
Tobacco:	No problems expected.