Brand & Generic Names

Cotazym	Pancrease MT4
Cotazym E.C.S.	Pancrease MT10
Cotazym-S	Pancrease MT16
Cotazym-65B	Protilase
Enzymase-16	Ultrase MT 12
Ilozyme	Ultrase MT 20
Ku-Zyme HP	Ultrase MT 24
Lipancreatin	Viokase
Pancoate	Zymase
Pancrease

Basic Information

• Habit forming? No
• Prescription needed? Yes
• Available as generic? No
• Drug class: Enzyme (pancreatic)

Uses

• Replaces pancreatic enzyme lost due to surgery or disease.
• Treats fatty stools (steatorrhea).

Dosage & Usage Information

How to take:
Tablets, capsules or delayed-release capsules--Swallow whole. Do not take with milk or milk products.
Powder--Sprinkle on liquid or soft food.

When to take:
Before meals.

If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose).

What drug does:
Enhances digestion of proteins, carbohydrates and fats.

Time lapse before drug works:
30 minutes.

Don't take with:
Any other medicine without consulting your doctor or pharmacist.

Overdose

SYMPTOMS:
Shortness of breath, wheezing, diarrhea.

WHAT TO DO:

Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions.

Possible Adverse Reactions or Side Effects

Life-threatening:

None expected.

Common:

None expected.

Infrequent:

Diarrhea, asthma.

Rare:

• Rash, hives, blood in urine, swollen feet or legs, abdominal cramps.
• Nausea, joint pain.

Warnings & Precautions

Don't take if:
You are allergic to pancreatin, pancrelipase, or pork.

Before you start, consult your doctor:
If you take any other medicines.

Over age 60:
Adverse reactions and side effects may be more frequent and severe than in younger persons.

Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.

Breast-feeding:
Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply.

Infants & children:
Give under close medical supervision only.

Prolonged use:
No additional problems expected.

Skin & sunlight:
No problems expected.

Driving, piloting or hazardous work:
No problems expected.

Discontinuing:
Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment.

Others:
If you take powder form, avoid inhaling.

Possible Interaction with Other Drugs

GENERIC NAME	COMBINED EFFECT
------------------------	-----------------------
Calcium carbonate	Decreased effect of pancrelipase.
Iron supplements	Decreased iron absorption.
Magnesium hydroxide	Decreased effect of pancrelipase.

Possible Interaction with Other Substances

INTERACTS WITH	COMBINED EFFECT
---------------	---------------
Alcohol:	Unknown.
Milk.	Decreased effect of pancrelipase.
Cocaine:	Unknown.
Ice cream, milk	Decreased effect
products.	of pancrelipase.
Marijuana:	Decreased absorption of
	pancrelipase.
Tobacco:	Decreased absorption of
	pancrelipase.