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AMILORIDE & HYDROCHLOROTHIAZIDE
AMILORIDE & HYDROCHLOROTHIAZIDE
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AMILORIDE & HYDROCHLOROTHIAZIDE
BRAND AND GENERIC NAMES
Moduret
Moduretic
BASIC INFORMATION
Habit forming? No
Prescription needed? Yes
Available as generic? Yes
Drug class: Diuretic (thiazide),
antihypertensive
USES
Controls, but doesn't cure, high blood pressure.
Reduces fluid retention (edema), decreasing likelihood of
congestive heart failure.
DOSAGE & USAGE INFORMATION
How to take:
Tablet -- Swallow with liquid. If you can't swallow whole, crumble
tablet and take with liquid or food.
When to take:
At the same time each day, no later than 6 p.m.
If you forget a dose:
Take as soon as you remember up to 2 hours late. If more than 2
hours, wait for next scheduled dose (don't double this dose).
What drug does:
Forces sodium and water excretion, conserves potassium,
reducing body fluid.
Relaxes muscle cells of small arteries.
Reduced body fluid and relaxed arteries lower blood pressure.
Time lapse before drug works:
2-6 hours. May require several weeks to lower blood pressure.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Cramps, weakness, drowsiness, weak pulse, coma, rapid, irregular
heartbeat.
WHAT TO DO:
Dial 0 (operator) or 911 (emergency) for an ambulance or
medical help. Then give first aid immediately.
See EMERGENCY INFORMATION.
POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
SYMPTOMS WHAT TO DO
Life-threatening:
None expected.
Common:
Increased thirst, Discontinue. Call
irregular heartbeat, doctor right away.
cramps in muscles,
numbness and tingling in
hands and feet, thready
pulse, shortness of breath.
Tiredness, weakness, Continue. Call doctor
dry mouth, diarrhea, when convenient.
headache, appetite loss,
nausea.
Infrequent:
Mood changes, Continue. Call doctor
constipation, decreased when convenient.
sex function,
dizziness,
lightheadedness.
Rare:
Jaundice; unusual Discontinue. Seek
bleeding or bruising; emergency treatment.
abdominal pain with nausea
and vomiting; sore throat,
fever, sores in mouth; hives,
skin rash; joint pain.
WARNINGS & PRECAUTIONS
Don't take if:
You are allergic to amiloride or any thiazide diuretic drug.
Before you start, consult your doctor:
If you are allergic to any sulfa drug.
If you have gout, diabetes, heart disease.
If you have liver, pancreas or kidney disorder.
Pregnancy:
Risk to unborn child outweighs drug benefits. Don't use.
Infants & children:
Don't give to infants or young children unless prescribed and
monitored by your physician.
Prolonged use:
You may need medicine to treat high blood pressure for the rest
of your life.
Skin & sunlight:
May cause rash or intensify sunburn in areas exposed to sun or
sunlamp. Avoid overexposure.
Driving or hazardous activities:
Don't drive or pilot aircraft until you learn how medicine
affects you. Don't work around dangerous machinery. Don't climb
ladders or work in high places. Danger increases if you
drink alcohol or take medicine affecting alertness and reflexes,
such as as antihistamines, tranquilizers, sedatives, pain
medicine, narcotics and mind-altering drugs.
Discontinuing:
Don't discontinue without medical advice.
Others:
Hot weather and fever may cause dehydration and drop in blood
pressure. Dose may require temporary adjustment. Weigh daily and
report any unexpected weight decreases to your doctor.
May cause rise in uric acid, leading to gout.
May cause blood-sugar rise in diabetics.
Get periodic check-ups and potassium-level laboratory tests.
POSSIBLE INTERACTION WITH OTHER DRUGS
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| Allopurinol |
Decreased allopurinol effect. |
| Antidepressants, |
Dangerous drop in |
| tricyclic (TCA, |
blood pressure. Avoid |
| see Drugs Glossary) |
combination unless under medical |
| |
supervision. |
| Antihypertensives |
Increased effect of |
| (other, see Drugs |
both drugs. |
| Glossary) |
| Barbiturates |
Increased |
| (see Drugs Glossary) |
hydrochlorothiazide effect. |
| Beta-adrenergic |
Increased antihypertensive effect. |
| blockers (see Drugs |
Dosages of both drugs may require |
| Glossary) |
adjustments. |
| Blood-bank blood |
Increased potassium levels. |
| Cortisone drugs |
Excessive potassium |
| (see Drugs Glossary) |
loss that causes dangerous heart |
| |
rhythms. |
| Digitalis |
Excessive potassium |
| preparations |
loss that causes dangerous heart |
| (see Drugs Glossary) |
rhythms. |
| Diuretics (thiazide, |
Increased diuretic effect. |
| see Drugs Glossary) |
|
| Diuretics (other, |
Increased effect of |
| see Drugs Glossary) |
both drugs. |
| Indapamide |
Increased diuretic effect. |
| Lithium |
Possible lithium toxicity. |
| MAO inhibitors |
Increased |
| (see Drugs Glossary) |
hydrochlorothiazide effect. |
| Nitrates |
Excessive |
| (see Drugs Glossary) |
blood-pressure drop. |
| Oxprenolol |
Increased antihypertensive effect. |
| |
Dosages may require adjustment. |
| Probenecid |
Decreased probenecid effect. |
| Sodium bicarbonate |
Decreased potassium levels. |
POSSIBLE INTERACTION WITH OTHER SUBSTANCES
| Marijuana: |
May increase blood pressure. |
| Tobacco: |
None expected. |
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From Complete Guide to Pediatric Symptoms, Illness & Medications by H. Winter Griffith, M.D. Copyright by Putnam Publishing
Group. Electronic rights by Medical Data Exchange.
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