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ANTICOAGULANTS, ORAL

ANTICOAGULANTS, ORAL
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ANTICOAGULANTS, ORAL

BRAND & GENERIC NAMES

ANISINDIONE

Anthrombin-K
Coumadin
Danilone
DICUMAROL
Dufalone
Hedulin
Liquamar
Marcumar
Marevan
Melitoxin
Miradon
Panwarfin
PHENINDIONE
PHENPROCOUMON
Sofarin
WARFARIN POTASSIUM
WARFARIN SODIUM
Warfilone
Warnerin

BASIC INFORMATION

Habit forming? No

Prescription needed? Yes

Available as generic? Yes

Drug class: Anticoagulant

USES

Reduces blood clots. Used for abnormal clotting inside blood
vessels.

DOSAGE & USAGE INFORMATION

How to take:
Tablet -- Swallow with liquid. If you can't swallow whole, crumble
tablet and take with liquid or food.
When to take:
At the same time each day.
If you forget a dose:
Take as soon as you remember up to 12 hours late. If more than
12 hours, wait for next scheduled dose (don't double this dose).
Inform your doctor of any missed doses.
What drug does:
Blocks action of vitamin K necessary for blood clotting.

Time lapse before drug works:
36 to 48 hours.
Don't take with:
Any other medicines, even over-the-counter drugs such as cough
and cold medicines, nose drops, diet pills, laxatives or
caffeine, without consulting your doctor.
OVERDOSE
SYMPTOMS:
Bloody vomit and bloody or black stools, red urine.
WHAT TO DO:

Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately.

See EMERGENCY INFORMATION.

POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS

SYMPTOMS WHAT TO DO

Life-threatening:
None expected.
Common:
Bloating, gas. Continue. Tell doctor at next
visit.
Infrequent:

Black stools or Discontinue. Seek bloody vomit, emergency treatment. coughing up blood.

Rash, hives, itch, Discontinue. Call blurred vision, doctor right away. sore throat, easy bruising, bleeding, cloudy or red urine, back pain, jaundice, fever, chills, fatigue, weakness.

Diarrhea, cramps, Continue. Call doctor nausea, vomiting, when convenient. swollen feet or legs, hair loss. Rare:

Necrosis of skin Discontinue. Seek emergency treatment

Dizziness, headache, Discontinue. Call mouth sores. doctor right away.

WARNINGS & PRECAUTIONS

Don't take if:

You have been allergic to any oral anticoagulant.

You have a bleeding disorder.

You have an active peptic ulcer.

You have ulcerative colitis.

Before you start, consult your doctor:

If you take any other drugs, including non-prescription drugs.

If you have high blood pressure.

If you have heavy or prolonged menstrual periods.

If you have diabetes.

If you have a bladder catheter.

If you have serious liver or kidney disease.

If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Infants & children: Use only under doctor's supervision. Prolonged use: No age-related problems expected. Skin & sunlight: No age-related problems expected.

Driving or hazardous activities:

Avoid hazardous activities that could cause injury.

Don't drive if you feel dizzy or have blurred vision. Discontinuing: Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment. Others: Carry identification to state you take anticoagulants.

POSSIBLE INTERACTION WITH OTHER DRUGS

Acetaminophen Increased effect of anticoagulant.

Allopurinol Increased effect of anticoagulant.

Amiodarone Increased effect of anticoagulant.

Androgens Increased effect of anticoagulant.

Antacids Decreased effect of

(large doses, anticoagulant.

see Drugs Glossary)

Antibiotics Increased effect of

(see Drugs Glossary) anticoagulant.

Anticonvulsants Increased effect of

(hydantoin, see both drugs.

Drugs Glossary)

Antidepressants, Increased effect of

tricyclic (TCA, anticoagulant.

see Drugs Glossary)

Antidiabetics Increased effect of

(oral, see Drugs anticoagulant.

Glossary)

Antihistamines Unpredictable increased

(see Drugs Glossary) or decreased effect of

anticoagulant.

Aspirin Possible spontaneous bleeding.

Barbiturates Decreased effect of

(see Drugs Glossary) anticoagulant.

Benzodiazepines Unpredictable increased

(see Drugs Glossary) or decreased anticoagulant effect.

Calcium supplements Decreased anticoagulant effect.

Carbamazepine Decreased effect of anticoagulant.

Fluoxetine May cause confusion, agitation,

convulsions and high blood

pressure. Avoid combining.

Griseofulvin Decreased effect of anticoagulant.

Non-steroidal Increased risk of

anti-inflammatory bleeding.

drugs (NSAIDs, see

Drugs Glossary)

Phenytoin Decreased phenytoin levels.

Rifampin Decreased effect of anticoagulant.

Suprofen Increased risk of bleeding.

Vitamin K Decreased effect of anticoagulant.

POSSIBLE INTERACTION WITH OTHER SUBSTANCES

Marijuana: None expected.

Tobacco: None expected.

From Complete Guide to Pediatric Symptoms, Illness & Medications by H. Winter Griffith, M.D. Copyright by Putnam Publishing Group. Electronic rights by Medical Data Exchange.