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Acid Mucopolysaccharides (AMPs)
Acid Mucopolysaccharides (AMPs)
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Acid Mucopolysaccharides (AMPs)
Category: Urine sugars, ketones and mucopolysaccharides.
Subcategory: Carbohydrate and fat-metabolism tests.
Material studied: Urine.
Estimated cost of test: $29.50.
Patient time for test: 24+ hours.
Reliability of test results: Very good; specificity very good for mucopolysaccharidoses.
Available as home self-test? No.
Note: Test helps determine the efficiency of carbohydrate metabolism in infants. Test requires a 24-hour urine specimen.
BEFORE THE TEST
Purpose of test:
Diagnoses mucopolysaccharidosis*.
Where is test performed?
Commercial laboratory, hospital, doctor's office.
Who performs test?
Lab technician, nurse, doctor.
Risks and precautions:
If the infant is receiving heparin therapy* and must continue it, remind the operator who accepts the specimen.
Patient preparation:
Activity--No changes necessary.
Diet--No changes necessary.
Medicines--Inform the person performing the test if your child has recently taken any medications listed under Taking these drugs may affect test results. You may be asked not to give him this medication before the test.
Disrobing--None required.
THE TEST
Sensory factors:
Seeing--Urine color varies greatly, whether your child is healthy or ill. Tell the technician, nurse or doctor if urine appears red, cloudy, smoky or has any other strange appearance or color.
Smelling--Urine may have a noticeably abnormal odor if it is concentrated. Many drugs and foods affect the smell and other characteristics of urine. Report any unusual odors to the technician, nurse or doctor.
Feeling--Collecting a urine specimen should not cause pain. If it seems to, notify the technician, nurse or doctor.
Other senses (touch, hearing, taste)--Not affected.
Equipment used:
Sterile urine container.
Urine-collection device--a plastic bag with adhesive backing around the opening.
Description of test:
See Appendix 4 for instructions on collecting a urine sample.
Collect a 24-hour urine specimen. See Appendix 10 for instructions.
Refrigerate the specimen, or keep it on ice during the collection period.
Take urine sample to laboratory for analysis.
AFTER THE TEST
Immediate post-test care:
None.
Activity after test:
Remove the collection device carefully to prevent skin irritation. Wash the area with soap and water where the adhesive bandage was attached to the infant's skin.
Watch for irritation. Report to your doctor if it occurs.
Time before test results available:
Test requires only a few minutes in the laboratory. Time before results are reported to the doctor or patient varies from a few minutes to a few days.
TEST RESULTS
Test values:
Test results are determined by Dishe carbazole reaction*.
Normal values:
Normal AMP values vary with age.
Age in months AMPs**
2 8 to 30
4 7 to 27
6 6 to 24
8 4 to 22
10 2 to 16
12 0 to 15
14 0 to 12
**AMPs = mg glucuronic acid/24 hours
g creatinine/24 hours
What HIGH or INCREASED may indicate:
Mucopolysaccharidosis*.
Taking these drugs may affect test results:
Heparin.
Other factors that may affect test reliability of test results:
Failure to collect all urine during the test period.
Failure to store the specimen properly.
*See Glossary.
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From Complete Guide to Medical Tests by H. Winter Griffith, M.D. Copyright by Fisher Books. Electronic rights by Medical Data Exchange.
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