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APPENDIX 6: DRUGS THAT INFLUENCE ROUTINE-URINALYSIS RESULTS
Drugs that may change urine color (color of urine)
Alcohol (light).
Chlorpromazine hydrochloride (dark).
Chlorzoxazone (orange to purple-red).
Deferoxamine mesylate (red).
Fluorescein sodium I.V. (yellow-orange).
Furazolidone (brown).
Iron salts (black).
Levodopa (dark).
Metronidazole (dark).
Methylene blue (blue-green).
Nitrofurantoin (brown).
Oral anti-coagulants, indandione derivatives (orange).
Phenazopyridine (orange-red, orange-brown, red).
Phenolphthalein (red to purple-red).
Phenosulfonphthalein (pink or red).
Quinacrine (deep yellow).
Riboflavin (yellow).
Rifampin (red-orange).
Sulfasalazine (orange-yellow).
Sulfobromophthalein (red).

Drugs that may cause urine odor
Antibiotics.
Paraldehyde.
Vitamins.

Drugs that may decrease pH
Ammonium chloride.
Ascorbic acid.
Diazoxide.
Methenamine.
Metolazone.

Drugs that may increase pH
Acetazolamide.
Amphotericin-B.
Mafenide.
Potassium citrate.
Sodium bicarbonate.

Drugs that may cause false-positive results for protein
Acetazolamide (Combistix(R), Labstix(R)).
Aminosalicylic acid (sulfosalicylic acid or Extons method).
Cephalothin in large doses (sulfosalicylic-acid method).
Nafcillin (sulfosalicylic-acid method).
Sodium bicarbonate (all methods).
Tolbutamide (sulfosalicylic-acid method).
Tolmetin (sulfosalicylic-acid method).

Drugs that may cause proteinuria
Amikacin.
Amphotericin-B.
Bacitracin.
Gentamicin.
Gold preparations.
Kanamycin.
Neomycin.
Netilmicin.
Penicillin.
Phenylbutazone.
Polymyxin B.
Streptomycin.
Sulfonamides.
Tobramycin.
Trimethadione.

Drugs that may cause false-positive results in urine
Aminosalicylic acid (Benedict's test).
Ascorbic acid (Clinistix(R), Clinitest(R) tablets,
Diastix(R), Tes-Tape(R)).
Cephalosporins (Clinitest(R) tablets).
Chloral hydrate (Benedict's test).
Chloramphenicol (Benedict's test, Clinitest(R) tablets).
Isoniazid (Benedict's test).
Levodopa (Clinistix(R), Clinitest(R) tablets,
Diastix(R), Tes-Tape(R)).
Methyldopa (Tes-Tape(R)).
Nalidixic acid (Benedict's test, Clinitest(R) tablets).
Nitrofurantoin (Benedict's test).
Penicillin G in large doses (Benedict's test).
Phenazopyridine (Clinistix(R), Diastix(R), Tes-Tape(R)).
Probenecid (Benedict's test, Clinitest(R) tablets).
Salicylates (Clinitest(R) tablets, Clinistix(R),
Diastix(R), Tes-Tape(R)).
Streptomycin (Benedict's test).
Tetracyclines (Benedict's test, Clinitest(R) tablets,
Clinistix(R), Diastix(R), Tes-Tape(R)).

Drugs that may cause glycosuria
Ammonium chloride.
Asparaginase.
Carbamazepine.
Corticosteroids.
Dextrothyroxine.
Lithium carbonate.
Nicotinic acid (large doses).
Phenothiazines (long-term).
Thioazide diuretics.

Drugs that may increase white blood cells in urine
Allopurinol.
Ampicillin.
Aspirin toxicity.
Kanamycin.
Methicillin.

Drugs that may cause red blood cells in urine
Amphotericin-B.
Coumarin derivatives.
Methenamine (large doses).
Methicillin.
Para-aminosalicylic acid.
Phenylbutazone.
Sulfonamides.

Drugs that may cause false-positive results for ketones
in urine
Levodopa (Ketostix(R), Labstix(R)).
Phenazopyridine (Ketostix(R), Gerhardt's(R) reagent strip shows atypical color).
Phenolsulfonphthalein (Rothera's test).
Phenothiazines (Gerhardt's(R) reagent strips show atypical color).
Salicylates (Gerhardt's(R) reagent strips show reddish color).
Sulfobromophthalein (Bili-Labstix(R)).

Drugs that may cause ketones in urine
Ether (anesthesia).
Isoniazid (intoxication).
Isopropyl alcohol (intoxication).
Insulin (excessive doses).

Drugs that may cause casts
Amphotericin-B.
Aspirin toxicity.
Bacitracin.
Ethacrynic acid.
Furosemide.
Gentamicin.
Griseofulvin.
Isoniazid.
Kanamycin.
Neomycin.
Penicillin.
Radiographic agents.
Streptomycin.
Sulfonamides.

 
From Complete Guide to Medical Tests by H. Winter Griffith, M.D. Copyright by Fisher Books. Electronic rights by Medical Data Exchange.

 

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