Facts About Endometriosis
Endometriosis is a common yet poorly understood disease. It can strike women of any
socioeconomic class, age, or race. It is estimated that between 10 and 20 percent of
American women of childbearing age have endometriosis. While some women with endometriosis
may have severe pelvic pain, others who have the condition have no symptoms. Nothing about
endometriosis is simple, and there are no absolute cures. The disease can affect a woman's
whole existence-her ability to work, her ability to reproduce, and her relationships with
her mate, her child, and every one around her.
The National Institute of Child Health and Human Development (NICHD), part of the
Federal Government's National Institutes of Health (NIH), conducts and supports research
on the various processes that determine the health of children adults, families, and
populations. As part of NICHD's mandate in the reproductive sciences, NICHD has
established a Reproductive Medicine Network linking several institutions across the
country. While this cooperative effort focuses on other important issues such as
infertility and various male and female reproductive disorders, developing an optimal
treatment for endometriosis is one of its primary goals.
What Is Endometriosis?
The name endometriosis comes from the word "endometrium," the
tissue that lines the inside of the uterus. If a woman is not pregnant this tissue builds
up and is shed each month. It is discharged as menstrual flow at the end of each cycle. In
endometriosis, tissue that looks and acts like endometrial tissue is found outside the
uterus, usually inside the abdominal cavity.
Endometrial tissue residing outside the uterus responds to the menstrual cycle in a way
that is similar to the way endometrium usually responds in the uterus. At the end of every
cycle, when hormones cause the uterus to shed its endometrial lining, endometrial tissue
growing outside the uterus will break apart and bleed. However, unlike menstrual fluid
from the uterus, which is discharged from the body during menstruation, blood from the
misplaced tissue has no place to go. Tissues surrounding the area of endometriosis may
become inflamed or swollen. The inflammation may produce scar tissue around the area of
endometriosis. These endometrial tissue sites may develop into what are called
"lesions," "implants," "nodules," or "growths."
Endometriosis is most often found in the ovaries, on the fallopian tubes, and the
ligaments supporting the uterus, in the internal area between the vagina and rectum, on
the outer surface of the uterus, and on the lining of the pelvic cavity. Infrequently,
endometrial growths are found on the intestines or in the rectum, on the bladder, vagina,
cervix, and vulva (external genitals), or in abdominal surgery scars. Very rarely,
endometrial growths have been found outside the abdomen, in the thigh, arm, or lung.
Physicians may use stages to describe the severity of endometriosis. Endometrial
implants that are small and not widespread are considered minimal or mild endometriosis.
Moderate endometriosis means that larger implants or more extensive scar tissue is
present. Severe endometriosis is used to describe large implants and extensive scar
tissue."Staging endometriosis is vitally important because all women with
endometriosis are not the same."NICHD Researcher
What Are The Symptoms?
Most commonly, the symptoms of endometriosis start years after menstrual periods begin.
Over the years, the symptoms tend to gradually increase as the endometriosis areas
increase in size. After menopause, the abnormal implants shrink away and the symptoms
subside.
The most common symptom is pain, especially excessive menstrual cramps (dysmenorrhea)
which may be felt in the abdomen or lower back or pain during or after sexual activity
(dyspareunia). Infertility occurs in about 30 to 40 percent of women with endometriosis.
Rarely, the irritation caused by endometrial implants may progress into infection or
abscesses causing pain independent of the menstrual cycle. Endometrial patches may also be
tender to touch or pressure, and intestinal pain may also result from endometrial patches
on the walls of the colon or intestine.
The amount of pain is not always related to the severity of the disease-some women with
severe endometriosis have no pain; while others with just a few small growths have
incapacitating pain.
Endometrial cancer is very rarely associated with endometriosis, occurring in less than
1 percent of women who have the disease. When it does occur, it is usually found in more
advanced patches of endometriosis in older women and the long-term outlook in these
unusual cases is reasonably good.
"While endometriosis is not a malignant disease, it does cause alot of suffering
and pain."
NICHD Researcher
How Is Endometriosis Related To Fertility Problems?
Severe endometriosis with extensive scarring and organ damage may affect fertility. It
is considered one of the three major causes of female infertility. However, unsuspected or
mild endometriosis is a common finding among infertile women and how this type of
endometriosis affects fertility is still not clear. While the pregnancy rates for patients
with endometriosis remain lower than those of the general population, most patients with
endometriosis do not experience fertility problems.
"We do not have a clear understanding of the cause-effect relationship of
endometriosis and infertility."
NICHD Researcher
What Is The Cause Of Endometriosis?
The cause of endometriosis is still unknown. One theory is that during menstruation
some of the menstrual tissue backs up through the fallopian tubes into the abdomen, where
it implants and grows. Another theory suggests that endometriosis may be a genetic process
or that certain families may have predisposing factors to endometriosis. In the latter
view, endometriosis is seen as the tissue development process gone awry.
Whatever the cause of endometriosis, its progression is influenced by various
stimulating factors such as hormones or growth factors. In this regard, NICHD
investigators are study- ing the role of the immune system in activating cells that may
secrete factors which, in turn, stimulate endometriosis.
In addition to these new hypotheses, investigators are continuing to look into previous
theories that endometriosis is a disease influenced by delayed childbearing. Since the
hormones made by the placenta during pregnancy prevent ovulation, the progress of
endometriosis is slowed or stopped during pregnancy and the total number of lifetime
cycles is reduced for a woman who had multiple pregnancies.
How Is Endometriosis Diagnosed?
Diagnosis of endometriosis begins with a gynecologist evaluating the patient's medical
history. A complete physical exam, including a pelvic examination, is also necessary.
However, diagnosis of endometriosis is only complete when proven by a laparoscopy, a minor
surgical procedure in which a laparoscope (a tube with a light in it) is inserted into a
small incision in the abdomen. The laparoscope is moved around the abdomen, which has been
distended with carbon dioxide gas to make the organs easier to see. The surgeon can then
check the condition of the abdominal organs and see the endometrial implants.
The laparoscopy will show the locations, extent, and size of the growths and will help
the patient and her doctor make better-informed decisions about treatment.
"Endometriosis is a long-standing disease that often develops slowly."
NICHD Researcher
What Is The Treatment?
While the treatment for endometriosis has varied over the years, doctors now agree that
if the symptoms are mild, no further treatment other than medication for pain may be
needed. For those patients with mild or minimal endometriosis who wish to become pregnant,
doctors are advising that, depending on the age of the patient and the amount of pain
associated with the disease, the best course of action is to have a trial period of
unprotected intercourse for 6 months to 1 year. If pregnancy does not occur within that
time, then further treatment may be needed.
For patients not seeking a pregnancy where treatment specific for the management of
endometriosis is required and a definitive diagnosis of endometriosis by laparoscopy has
been made, a physician may suggest hormone suppression treatment. Since this therapy shuts
off ovulation, women being treated for endometriosis will not get pregnant during such
therapy, although some may elect to become pregnant shortly after therapy is stopped.
Hormone treatment is most effective when the implants are small. The doctor may
prescribe a weak synthetic male hormone called Danazol, a synthetic progestin alone, or a
combination of estrogen and progestin such as oral contraceptives.
"We are finding good medical options without surgery."
NICHD Researcher
Danazol has become a more common treatment choice than either progestin or the birth
control pill. Disease symptoms are improved for 80 to 90 percent of the patients taking
Danazol, and the size and the extent of implants are also reduced. While side effects with
Danazol treatment are not uncommon (e.g., acne, hot flashes, or fluid retention), most of
them are relatively mild and stop when treatment is stopped. Overall, pregnancy rates
following this therapy depend on the severity of the disease. However, some recent studies
have shown that with mild to minimal endometriosis, Danazol alone does not improve
pregnancy rates.
It is important to remember that Danazol treatment is unsafe if there is any chance
that a woman is pregnant. A fetus accidentally exposed to this drug may develop
abnormally. For this same reason, although pregnancy is not likely while a woman is taking
this drug, careful use of a barrier birth control method such as a diaphragm or condom is
essential during this treatment.
Another type of hormone treatment is a synthetic pituitary hormone blocker called
gonadotropin-releasing hormone agonist, or GnRH agonist. This treatment stops ovarian
hormone production by blocking pituitary gland hormones that normally stimulate ovarian
cycles.
These hormones are currently being tested using different methods of administration.
One such treatment involves a drug that is administered as a nasal spray twice daily for 6
months and works by suppressing production of estrogen, which controls the growth of the
endometrial tissue. Other treatments being developed in this category include daily or
monthly hormone injections. One concern is the loss of bone mineral which occurs with this
type of hormone therapy. This may limit the duration and frequency of this type of
treatment.
While pregnancy rates for women with fertility problems resulting from endometriosis
are fairly good with no therapy and with only a trial waiting period, there may be women
who need more aggressive treatment. Those women who are older and who feel the need to
become pregnant more quickly or those women who have severe physical changes due to the
disease, may consider surgical treatment. Also, women who are not interested in pregnancy,
but who have severe, debilitating pain, may also consider surgery.
Conservative surgery attempts to remove the diseased tissue without risking damage to
healthy surrounding tissue. This surgery is called laparotomy and is performed in a
hospital under anesthesia. Pregnancy rates are highest during the first year after
surgery, as recurrences of endometriosis are fairly common. The specifics of the surgery
should be discussed with a doctor.
Some patients may need more radical surgery to correct the damage caused by untreated
endometriosis. Hysterectomy and removal of the ovaries may be the only treatment possible
if the ovaries are badly damaged. In some cases, hysterectomy alone without the removal of
the ovaries may be reasonable.
New surgical treatments are being developed that further utilize the laparoscope
instead of full abdominal surgery. During routine laparoscopy, the surgeon can cauterize
small areas of endometriosis. Other evolving techniques include using a laser during
laparoscopy to vaporize abnormal tissue. This involves a shorter recovery time.
Laparoscopy treatment is possible, however, only if the surgeon can see pelvic structures
clearly through the laparoscope. These newer techniques should be performed by surgeons
specializing in such delicate procedures. Although these techniques are promising, more
study is needed to determine if they yield results comparable to conventional surgical
management.
Where To Look For Answers...
Because endometriosis affects each woman differently, it is essential that the patient
maintains a good, clear, honest communication with her doctor. For the single truth about
endometriosis is that there are no clear-cut, universal answers.
If pregnancy is an issue, then age may affect the treatment plan. If it is not an
issue, then treatment decisions will depend primarily on the severity of symptoms.
Because these decisions can be difficult and confusing, there are organizations that
provide information and offer support and help to those who are affected by this disease.
Endometriosis Association
8585 North 76th Place
Milwaukee, Wisconsin 53223
(414) 355-2200
The American College of Obstetricians and Gynecologists
409 12th Street, SW
Washington, DC 20024-2188
(202) 638-5577
American Fertility Society
2140-llth Avenue South
Suite 200
Birmingham, Alabama 35205-2800
(205) 933-8494
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES
Public Health Service
National Institutes of Health
National Institute of Child Health and Human Development
NIH Publication number 91-2413
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